Apparatus and method for administering parenteral solutions



Dec. 22, 1953 H. w. ROSE 2,663,298

APPARATUS AND METHOD FOR ADMINISTERING PARENTERAL SOLUTIONS Filed June16, 1950 3 Sheets-Sheet l FIG. 1

IN VEN TOR.

H. W. ROSE Dec. 22, 1953 2,663,298

H. W. ROSE APPARATUS AND METHOD 'FOR ADMINISTERING PARENTERAL. SOLUTIONSFlled June 16, L950 3 SheetsSheet 2 F errr- 1. 'IIIIIIIIIIIIII. will/1fI/III/JI I N VEN TOR.

H. w ROSE Dec. 22, 1953 H. w. ROSE 2,663,298 APPARATUS AND METHOD FORADMINISTERING PARENTERAL SOLUTIONS Filed June 16, 1950 3 Sheets-Sheet 5IN VEN TOR.

. H; w. ROSE i-W ,6 e;

ATTORNEY Patented Dec. 22, 1953 APPARATUS; AND METHOD FOR .ADMINISQ fTERINQRARENTERALSQLUTIONS Rose, Arlington, Va."

- Application rum; 16, 1950, Serial No. 168,431

l l, 1 fThis invention relates to an apparatus and a method foradministering parenteral solutions and more particularly to a novelcontainer for the'storage of blood derivatives, such as dried plasma andthe like, and bloodsubstitutes, such as dextran and similar compounds,which may thusbe packaged and ithereafter dispensed from the containerwithoutpossibility of contactwith the air or contamination. 7

Present day imethodsiof storage and shipment oi the blood derivativesand substitutes with which we are here; concerned are particularly llllb r m h s es ia l t ue n. c ection with the furnishing of supplies ofplasma for use under emergency conditions as, for example, by our armedforces,-the approved method being costly,-complicated and diflicult toset up, including relatively heavy or weighty apparatus, and requiringan overall time interval for administration that is considered undulyprolonged.

The method currently employed contemplates the storage of dried humanplasma and distilled water in separate glass bottles, each bottle beingsealed by a penetrable, plastic closure member manufactured from sheetmaterial such as rubher. The bottles must be separately and carefullypacked, to minimize possibility of breakage, and a package or kit isprovided including a pair of needles, tubing, filter, observation tube,and intravenous needle. Distilled water and dried plasma are bottledunder vacuum and, after the bottle closures are carefully cleansed withalcohol or the like, a double ended needle is inserted into the opposedclosures, a so-called airway assembly being also employed, to permit thedistilled water to be drawn into the plasma bottle. During this stepofthe process it isnecessary to hold the bottles in substantially uprightposition with the water bottle immediately above the plasma bottle.Evenwith the exercise of extreme care plasma and water are subject tocon tamination either during the step of puncturing the closures or byreason of vacuum having been partially or wholly lost., l.

The needles are then removed from the closure of the plasma bottle whichis then gently agitated until the plasma is completely dissolved.

, The needle of the airway assembly is then removed from the waterbottle and inserted through the closure of the: plasma bottle which mustthen be suspended in inverted, upright position for 'administration' "ofthe transfusion. A second needle is inserted into the closure of theplasma bottle and this secondn'eedl'e carries a discharge tube,including'a plasma filter'and rea i s; (o1.12s2141)" observation tube,having an intravenous needle on the extremity thereofl Not only arethese preliminary s eps time consumingb'ut a support is required for;maintain-- h Pl m bottle n u ri t p si om uri the interval required foradministration ofthe transfusion. r 4

Moreover, the expenseof packaging is relatively g t sb t e: heavy-and;rea i y frangible as well as costly, addinglfurtherjtothe cost andpresenting problems of either disposition after use or storage andeventual shipment if. salvage is contemplated. "1);". f' It isaccordingly H a I major purpose ofthe' present inventiontoprovide anovel and distinetly improved methodof packaging and; shipment ;of bloodderivatives and blood substitutes, wherein all of the objectionablefeatures detailed hereabove have beeneliminated. r

It is afurther object of the present invention to provide a novel anddistinctlyimproved methodof packaging and s'hipment'otdried, humanplasma wherein all ofthe foregoing; difficulties of restorationof plas aand; a'dministr ionof transfusion are eliminated. r I

It is a furthenobject of the present inven ion to ,provide a novel,sterile .container for dried plasma and for the; distilled'--waterrequired 'for the restoration thereof which; may be readily manufacturedfrom inexpensive 'material ofzia character that may be convenientlydisposed of after use. i f

It is a furtherobject of the present invention to provide a'novel'container for dried plasma; and for the distilled waterrequiredfor the restoration thereof, which will" be flexible 'an'dinot readilyfrangible, substantially eliminating breakage and handling problemsduringthe; shipment thereof- 1; I J ,f if .Z'ii l It is a further objectof the present; invention to providea novel container of the classset-forth which is especially conformed so :as to house separately driedplasma. and the distilled water required for the restoration thereof; Ia novel clampingmember'being provided tofpreve'nt'coim mingling ofplasma and water. I It is :a further object-of the invention: to- 'providea novel container of the class setforthihav ing a discharge tube andintravenousne'edle' permanently attached thereto, the needle beingprotected against; damage, and ,contamination; "so that {nocontamination of restored plasma, orloss of tim r; (may occur throughany necessity for attaichinga'tube to the container to permit the usethereof as a dispenser during administration of the contents.

It is a still further object of the present invention to provide a novelpackage of particularly economical construction, for a container of theclass set forth, to permit the ready handling and shipment thereof withlittle possibility of damage to container and contents.

It is a still further object of the present invention to provide a novelmethod for commingling the contents of a container of the class setforth.

It is a still further object of the invention to provide a novel methodfor administering intravenously the restored contents of a container ofthe class set forth without any necessity for suspending the containerduring the transfusion interval.

It is a still further object of the present invention to provide a novelcontainer of the class set forth which may be manufactured withparticular economy, comprising a simple structure which may be used withespecial convenience and requires no additional appliances to permit theuse thereof as a dispenser or during the administration of the contentsintravenously.

Further objects and advantages of the invention will be apparent fromthe following specification taken in conjunction with the accompanyingdrawings, wherein:

Fig. 1 is a plan view of a novel blood plasma container, constructed inaccordance with the present invention;

Fig. 2, a vertical sectional view through the container of Fig. l, aportion of the discharge tube being broken away, illustrating the firststep in the filling thereof, a measured quantity of distilled waterhaving been placed in the lower portion of the container;

Fig. 3, a vertical sectional view through the container, a portion ofthe discharge tube being broken away, illustrating the second step ofthe filling process, air having been evacuated from the lower portion ofthe container and a clamp having been applied to the neck portion of thecontainer, immediately above the filled, lower portion;

Fig. 4, a vertical sectional view through the container, a portion ofthe discharge tube being broken away, illustrating the third step of thefilling process, a measured quantity of dried blood plasma or otherblood derivative or substitute having been placed in the upper portionof the container;

Fig. 5, a fragmentary, vertical sectional view through the container,illustrating the fourth I step of the filling process, air having beenevacuated from the upper portion of the container and the mouth thereofhaving been scaled;

Fig. 6, a horizontal sectional view through the lower portion of thecontainer, taken on the line 6-6 of Fig. 2;

Fig. 7, a longitudinal sectional view through the filled container,illustrating a novel manner in which the container may be packaged forshipment;

Fig. 8, a perspective view illustrating the container in position readyfor use, a portion of the discharge tube being broken away, the clamp onthe neck portion having been removed and the dried blood plasma anddistilled water having been combined;

Fig. 9, a perspective view of a preferred form of clamp used foreffecting a seal between the upper and lower portions of the container;

Fig. 10, a longitudinal detail sectional view through the clamp and theadjacent portions of the container, illustrating the clamp broken, priorto effecting the removal thereof;

Fig. 11, a longitudinal sectional view through the broken clamp andassociated parts disclosed in Fig. 10, illustrating the method forremoval of clamp and .tie member;

Fig. 12, an elevational View of the intravenous needle and novelprotective cover applied to the extremity of the discharge tube;

Fig. 13, a vertical sectional view taken through the intravenous needle,the protective cover having been removed;

Fig. 14, a fragmentary vertical sectional view taken through the neckand upper portions of the container, illustrating a modified form ofstrainer element;

Fig. 15, a perspective view of a modified form of clamp, illustratingthe component parts thereof in expanded position; and

Fig. 16, a longitudinal sectional view through the modified clamp ofFig. 15, illustrating the clamp applied to the neck portion of thecontainer.

As illustratedmore particularly in Fig. 1 of the drawings, the novelcontainer It comprises upper and lower portions II and i2, respectively,and an intermediate connecting or neck portion 13 of substantiallyreduced width. The bottom it of the lower portion is closed and has adischarge tube 26 mounted centrally thereof, as will be hereinafter morefully described. The upper extremity of the top portion H is open toprovide a mouth whereby the bag-like container may be filled withdistilled water and dried blood plasma.

Preferably, the container H] is formed from suitable plastic, sheetmaterial, it having been found in practice that sheet materialn1anufaetured from polyethylene and/or polyvinyl deriva tives isparticularly desirable, combining the advantageous characteristics oftensile strength, flexibility, resiliency, and transparency. Further, novulcanization takes place when layers of such material are maintainedunder pressure, an essential issue in connection with the instantdevice. In the preferred embodiment of the in vention illustrated asingle sheet of such material has been bent upon itself as indicated atit to provide superimposed layers of plastic material, the sides ofwhich have been preformed to comprise upper and lower portions H and i2,respectively, connected by a restricted neck portion 1 2. One layer ofsuch material extends beyond the open mouth of the container, asindicated at 15, to provide means for appropriately sealing such. mouth.The side edges I6 of the container are permanently united as indicated,as will be more readily apparent from an examination of Figs. 1 and 6 ofthe drawings, by cementing or other related step as is well known inconnection with plastic materials of the class with which we are hereconcerned. There has thus been provided a relatively tough, resilientand flexible container including spaced upper and lower bag-likeportions designed for use as separate receptacles and connected by atubular, restricted neck.

The lower portion 12 is intended to receive a measured quantity ofdistilled water while the upper portion I l serves as the receptacle forthe dried blood plasma and suitable sealing means is provided formaintaining the contents of these portions separate and preventing theinadvertent commingling thereof until it is desired to restore theplasma for transfusion or other puredge.

acemes poses. Thus the upper and lowerportions ofthe tenamer comprise,in effect, p te-"r epcomprises a generally U'-sh aped Supporting and Ispacing member I! including a substantially verticallydisposed end walll 8 and outwardly flaring legs l9. These legs are spaced farthest-apartat'th'eir extremities Zfiwhich may be sharply, outwardly inclined andprovided with a rounded Arcuate portions 2| join the end'wall l8 and thelegs 19, the over-all'height of the end wall being preferably greaterthan the distance between the inner extremities of the legs. 1Prefierably the legs 19 are formed with opposed arcuate' transversecross-sectional configurations,

for a purpose which will hereafter become more fully apparent.

" It will be obvious that'the filling steps maybe reversed, i. e., driedplasma may be placed in the lower portion [2 and distilled water in theupper portion 1 l, without in any manner affecting the functioning ofthe apparatus. By such an arrangement any necessity for a drying step,subsequent to the introduction ofLliquid-and prior lies the end wall andlegs of the clamp, in parallel relation with respect thereto, and theupper and lower portions or receptaclesl! and 12, extend immediatelybeyond the extremities?!) of the legs of the clamp. It willbe observedthat the configuration of the clamp is such that no sharp surfaces arepresented for contact with thermaterial of the container, such as'mightresult in vulcanization of the'plastic material orininjury thereto. Asuitable tie: member is then posi tioned about the restricted neckportion of the container, in embracing relationship with respect to theclamping member. Various forms of tie members may be employed, apreferred embodiment comprising an adhesive member 22 intended to bewrapped around the'legs I9 and overlying neck portion, the innerextremity of such a tie member being free, from'adhesive so as. not toadhesively unite with the material of the container. Thus the firstlayer or two of the .tie member 22 will not adhere to the restrictedneck portion whilethe outer layers'of such member will adhere to thelower layers thereof, obviating any possibility of passage of eitherdistilled'v /ater or dried plasma from one portion of the container tothe other during such time as the neck portion I3 is engaged with theclamping member 11. The arcuate portions, 2| of the clamp and theangularly directed extremities 23 of the legs thereof effectivelyprevent any possibilityof in-' advertent displacement of the tie member22.

As will be more readily apparent from an examination of Figs. and ll ofthe drawings, the outer extremity 22 of the tie member 22 is also freeof adhesive and comprises aconvenient tab which maybe grasped and makesthe task of manually removing or unwrapping the tie memberfrom the clampIT a particularly simple one. It is contemplated, however, thatthis'clamp will be readily frangible whereby fracture" thereof, as willbe more fully described hereinafter, results in practicallyinstantaneousseparation of tie member and clamp from the restrictedportion l3 of the container.

Preferably the clamping member ll'is'formed from a suitable plasticmaterial which will be readily frangible so that,' when it "is' desiredto remove theclamp; pressure" upon the 'ei ztren'riities of theilegs'Will -result in fracture of the end wall' l'il; as isparticularlyillustrated in Figs. 10

and 11 of -"the drawings;- 'TheT collapse of this end wall,occasioned=by s'uchiracture, will permit the lateralwithdrawaliof'thetie member '22 as the pieces of th"'clariiping "member fall from place,

freeingithe neckportionof r the container;

modified form of? clamping member has been "illustrated :in-I'Figsk :15and 16 of the drawings. In' this embodiment theclamp comprises an inner:U-shaped member:'23 of arcuate cross sectional' conformation: provided1 with upstanding rounded ribs' 24pn the' ends' thereof. Preferably the"distance betweensu'ch' ribs is but slightly greater than the width ofthe restricted neck portion I 3' 'ofzthe; container. An outer,complementarily arcuat'e' and: resilient clamping member 25 is provided,for engagement with the surface of inner member 23:.between the ribs 24.In use-,"thefrestricted necks-portion of the container isplaced'up'ontheiinner member 23 in overlying relationship and the outerclamping memberl2 5 is snapped thereupon;""'Firm pressure is thusobtained, efie'ctively' preventing passage of contents between the upperand lower portions of the container until theclampingm'embers thusdescribed are manually. removed" a Any rsuitable plastic or othermaterial; :having ..:the required degree of flexibility, may beutilizedrfor the manufacture of the clamping members-:23rand 25, and,since no fracture thereof isint'ended' connection with disengagementfromtliec'ontainer, such members aresusceptible ofreuser The lowerportion orreceptacle 12 preferably is provided 'witha dischargeor'injectiontube 26. The bottom wallof the receptacle 12 maybe providedwith an' aperture 21,? positioned substantially centrally" thereof; andthe inner extremity of the tube is inserted=through thisaperture. Aflange 28 is provided 'on- 'the" inner extremity of the'tubel 26 and"this "flange is cemented or otherwise united to the 'material'of' thecontainer immediately surrounding the aperture-'21. Preferably theflange 28 includesa suitable strainer element-29 provided-with'aplurality of extreme- 1y small apertures which will permit the passageof fluidtherethrough but which will effectively 'prevent possibility ofany particles or clumps of dried'plasma entering into the-dischargetube.

'A-clamping member-30 is: applied to the discharge tube 26immediatelyadjacent the receptacle l2*to' prevent'any distilled water from enteringany substantial-distance into the tube prior totheuse of the device' foradministering transfusion. If desired, this clamping member may i besimilar to the'clamping' member H, ex cept on a materially smallerscale, and a tie member 3|, 'similarto theltie member 22, may be. used.It .has been found in practice that when clamping members-of thischaracter, are employed there is far'less likelihood "of deformation "ofthei'materiali' clamped thereupon despite comparatively long stora'geintervals.

' Thedischarge' tubezZB is provided on the lowerextremityi'thereof*witli an intravenous needle 32 as is well known inthis art..--'Preferably. the intravenous needleiincludes an enlargedengaging' portion33 receivable within the tube 26 and includinga-shoulder34"limiting entry into the tube: .To protect the needleagainst contamination a plastidorother suitable casing 35 isprovided,..the"op en'inner extremity. of such casing being designedfor-frictional engagement with the 1discha'rgetube. 26; immediately:adjacent the lower extremity thereof. The tube 26 is further provided,intermediate the extremities thereof, with a plasma filter 36of-conventional constructions, also as is well known in the art.

The discharge tube 26 is further provided with a secondary clampingmember 44 positioned adiacent the lower extremity of the tube, for apurpose to be more fully discussed hereinafter. Preferably thissecondary clamp comprises a substantially rectangular plate-like bodyprovided With'a substantially V-shaped aperture 45 positioned centrallythereof. The width of the widened extremity of this aperture is suchthat the discharge tube is freely receivable therein; movement of themember 44 transversely of the discharge tube will 'constrict the tubebetween the converging walls. of the aperture 45, thus effectivelypreventing flow of fluid through the discharge tube.

There has been illustrated in Figs. 2, 3, 4 and 5, the progressive stepsof the filling of the novel container described hereabove. Withparticular reference to Fig. 2, the clamping member 30 is first appliedto the discharge tube 26 and a measured quantity of distilled water W isplaced in the lower receptacle [2, the clamp 30 effectively preventingwater from entering into the tube 26 a sufiicient distance to. reach theplasma filter 36. Preferably the receptacle [2 if of a sufficient sizeto conveniently receive 600 cc. of distilled water, accepted practicesdictating that such water be pyrogen-free, sterile, and contain 0.1% ofcitric acid. The level of distilled water approaches the lower extremityof the reduced neck portion l3 of the container and air is thenexhausted from the receptacle I2, above the level of distilled water,and the clamping member [1 is then applied to said reduced or restrictedneck portion. This step of the filling process is illustrated in Fig. 3of the drawings.

After drying, the upper portion of the container or receptacle II isthen filled with dried, human plasma indicated conventionally at P.Preferably the size of this receptacle is such as to convenientlyreceive 500 cc. of plasma, accepted practices indicating the requirementfor a suitable and adequate preservative such, for example, asphenylmercuric borate in the proportion of 1:50,000. Air is thenexhausted from above the level of plasma and the mouth of the containeris then securely sealed. Such sealing is accomplished by bending thematerial l5 of one wall of the mouth of the container over upon thematerial of the opposed mouth wall and cementing or otherwisepermanently uniting the layers of material as indicated at 31,particular reference being had to Fig. 5 of the drawings. The nature ofthe plastic material from which the container is fabricated is such asto readily lend itself to such a permanent seal. Preferably, a suitableeyelet or grommet 38 is placed through the united layers of material 31,substantially centrally of the width of the closed mouth of the deviceto permit the subsequent hanging thereof upon a hook, nail or the like,should disposition be desirable during administration of the restoredfluid.

The novel receptacle having thus been filled, packaging for storage orshipment becomes a particularly simple matter, all issues of carefulhandling required for prior art devices by reason of frangibility havingbeen eliminated.

A preferred method of packaging has been illustrated in Fig. '7 of thedrawings where there is disclosed, somewhat diagrammatically, a boxlikecontainer 39 of any suitable material such as cardboard, fibreboard, orthe like, provided with a substantially U-shaped supporting spacer t0,the opposed legs of which are provided with vertically aligned apertures4i intended to receive the bellied surfaces of the filled receptacles IRand I2. Preferably the spacer 40 is positioned Within the container 39and the Water-filled receptacle I2 is positioned upon the lowermost legof the spacer so as to be supported within the aperture 4|. The upperleg of the spacer is then positioned upon the upper surface of thereceptacle I2 and the plasma-filled receptacle H is positioned so as tobe supported within the corresponding aperture 4! in said upper leg.Advantageously the upper leg is cut away or slightly shorter than thelower leg, to conveniently accommodate and support the clamping memberl7 and the reduced neck portion of the device, and is also provided withsuitable cut-away portions (not shown) to permit the free storage of theconvolutions of the discharge tube 28. Obviously the receptacles i l andi2 will tend to conform to the surfaces upon which they are supported,within the limits of flexibility of the plastic material from which thecontainer is manufactured. The package thus described may bemanufactured with particular economy, securely supports the containertherein against lateral displacement and eliminates any requirement forexcessive care in handling and shipment. Such a package may be droppedfrom the air, and parachuted into inaccessible areas, with substantialassurance that no damage to contents will occur.

In practice, when it is desired to restore the dried plasma fortransfusion or other purposes, the clamp I1 is fractured and the tiemember 22 removed from the neck portion it. The receptacles l l and 12are then gently agitated or manipulated until the dried plasma iscompletely dissolved, free passage of fluid between the receptaclesbeing had by reason of the tubular neck portion.

Upon completion of the restoration of the plasma, the clamp 30 isremoved from the discharge tube 28, the cap or casing 35 is removed fromthe intravenous needle 32, and sufficient restored blood derivative orsubstitute, as the case may be, is permitted to pass through thedischarge tube to vent all air therein, The tube 25 is then compressed,within the V-slot or aperture 45 of the secondary clamp 34, to shut offthe flow of fluid, and the intravenous needle 32 is inserted into thepatient. The tube is then released from constriction within thesecondary clamp and the transfusion may be administered Without loss oftime. If desired, the device may be suspended utilizing the grommet 33;however, it has been found that such suspension is neither necessary norparticularly advantageous, another method comprising folding the emptyupper receptacle or portion ll about the filled lower receptacle i2 andinserting or positioning thedevice beneath the buttocks or otheranatomical portion of the patient. Such practice is especially soundunder conditions of extreme sanguination or where the patient issuffering from circulatory depression, or the like, where it isnecessary to complete the transfusion with unusual rapidity.

It Will be readily understood that, with the novel device describedherein, there is no possibility of contamination of contents by air oroutside influence and that the only time consuming portion of theprocedure, other than that required for the transfusion per se, is thatrequired 9 for restoration of the plasma, a task made par-. ticularlysimple byreason of the flexibility of the material-from whichthecontainer is manufactured which lends itself with especial ease tomanual manipulation.

,'Ifhere has beenillustrated in Fig. 1% of the drawingsa modifled formof strainer element 42, which maybe substituted for the strainer 251-01used in addition thereto. The function of these strainers is to insurethat no particles of dried plasma may enter into the'dischargetube 26 toeither clog the filter or affect the rate of delivery of fluid throughthe tube. In this modified'form of strainer, a substantially cup-shapedmember is cemented or otherwise-secured in place at the lower extremityof the upper receptacle Hand immediately adj acent, the reduced ,neckportion of the device. This strainer is'provided with a plurality ofparticularly small apertures; 43 which will freely admit of the passageof distilled water from the receptacle, 12- to the receptacle I I i butwill effectively prevent particles or clumps of undissolved dried;plasma from passing therethrough. Moreover, the nature of the plasticmaterial from. which thedevice is formed is such that pressureupon, thereceptacle I2, during the manipulation thereof, incidental to therestoring of the plasma, will force distilled water from one receptacleto the' other,- effectively assisting the rate-of restoration.

It will be-obviousto thoseskilled in this art that air is not admittedto the apparatus during the intravenous administration of the contents,the collapsiblenature of the receptacle eliminat ing any necessityforthe utilization of air to replace fluid during the-dispensingthereof. Further}. since plastics of the character with which we arehere concerned may be" either largely transparent or translucent, asdesired, passage of fluid from the receptacle is susceptible of visualThe novel apparatus of the present invention is particularly light inweight and occupies a minimum of space. It may be readily packagedwithout requiring special cushioning of any sort and thus eliminatestransportation problems. During use, as well as during restoration ofthe plasma, no changes in the relationship of the parts are requiredsince it is, essentially, an integral structure. It is fully susceptibleof efficient operation without requiring additional equipment of anycharacter, and reduces the time required for preparation, prior totransfusion, a major extent.

Further, the novel method of administration, utilizing the body of thepatient as a weight or anchor, advantageously decreases the timerequired for transfusion, an element of particular importance oftentimes in direct ratio to the oritical condition of the patient.

It will be obvious to those skilled in this art that various changes maybe made in the invention'without departing from the spirit and scopethereof and therefore the invention is not limited by that which isillustrated in the drawing and described in the specification but onlyas is indicated in the appended claims.

What is claimed is: a

1. An apparatus for administering blood plasma comprising an elongatedflexible container formed from a single sheet of transparent plasticmaterial doubled upon itself to provide a closed bottom and an openmouth, one wall of said mouth extending beyond the other to provide anoverlapping extremity for sealing said mouth,

suspension means connected with. said. overlap..-.

ping sealed portion; the'longitudinal edges of said container beingunited, said container havinga. reduced. central portion providingcommunica-- thedispensing of restored plasma from said ap paratusclamping means on said discharge tube to prevent entry of fluid intosaid tube prior to the dispensing operation, and strainer means inv saidcontainer to prevent any particles of dried plasma from entering intosaid discharge tube.

2. An apparatus for administering blood plasma comprising anelongatedflexible containerformed from a single sheet oftransparentmaterial doubled upon itselfto provide a closed bottom, and an openmouth, one wall of said mouth being .providedwith an extended extremity,

for sealing said mouth, the longitudinal edges of said container being;united, said container havmg a reduced central portion providingcommunication between opposed bag+like receptacles, one receptacleadapted to contain dried plasma and the other receptaclezadaptedtocontain distilled water,.frangible. clamping means on said I reducedcentral portion whereby removal of said clamping, means will providefluid communication between said opposed receptacles to restore saidplasma to liquid :form, a discharge tube communicating with theinterior. of vsaid container at theclo'sed bottom thereof to' permit thedispensing of restored plasma from'said apparatus. and clamping means onsaid discharge tube to prevent the entry of fluid into said tube priorto the dispensing operation.

3. An apparatus for administering blood plasma comprising an elongatedflexible container manufactured from a single sheet of transparentmaterial bent upon itself to provide a ciosed bottom and an open mouth,one wall of said mouth being provided with an overlapping extremity forsealing said mouth, the longitudinal edges of said container beingunited, said container having a reduced central portion providingcommunication between opposed baglike receptacles, one receptacleadapted to contain dried plasma and the other receptacle adapted tocontain distilled water, clamping means for said reduced central portionwhereby removal of said clamping means will provide fluid communicationbetween said opposed receptacles to restore said plasma to liquid form,and a discharge tube communicating with the interior of said contamer atthe closed bottom thereof to permit the dispensing of restored plasmafrom said apparatus.

4. An apparatus for administering blood plasma comprising an elongatedflexible container 7 fabricated from a single sheet of flexible materialbent upon itself to provide a closed bottom and an open mouth portion,one wall of said mouth portion being provided with an overlappingextremity for sealing said mouth, the longitudinal edges of saidcontainer being united, said container having a reduced central portionproviding communication between opposed bag-like receptacles, onereceptacle adapted to contain dried plasma and the other receptacleadapted to contain distilled water, frangible clamping means for saidreduced central portion whereby fracture of said clamping mean's willprovide fluid communication between said opposed receptacles torestoresaidplasrna to liquidform, and a dischargetube communicating with theinterior of said, container at the closed bo ttom thereof to permitthedispensing of restored plasma from said apparatus, r

\ 5. An apparatus for administering blood plasma comprising an elongatedflexible contaiher having a reduced central portion intermediate theextremities thereof providing communication between opposed bag-likereceptacles, one receptacle adapted to contain dried plasma and theother receptacle adapted to contain distilled water, frangible clampingmeans for said reduced central portion whereby fracture of said clampingmeans will provide fluid connection between said opposed receptacles tocommingle said dried plasma and distilled water restoring said plasma toliquid form, a discharge tube communicating with the interior of one ofsaid receptacles to permit the dispensing of restored plasma from saidapparatus, and clamping means on said discharge tube to prevent entry offluid into said tube prior todispensing therefrom.

5.. An apparatus for administering blood plasma comprising a flexiblecontainer provided with av closed. bottom and an open mouth portion, theside. walls of saidcontainer being reduced intermediate the extremitiesthereof to provide two. bag-like receptacles havingatubular connectingportion therebetween, one receptacle adapted. to. contain dried plasmaand the other receptacle .adaptedto .contain distilled water, fluidconnection between the two. receptacles being had through said.tubularconnecting portion, anoverlapping portiononone wall of saidmouth portion for sealing said mouth, frangible clamping means for saidconnecting portion to prevent the commingling of the contents of saidreceptacles, whereby rupture of said means will permit the combining ofsaid dried plasma and said distilled water to restore said plasma toliquid form, and a discharge tube communicating with one of saidreceptacles to permit the dispensing of restored plasma from saidapparatus.

7. An apparatus for administering blood plasma comprising an elongatedflexible container, frangible clamping means engaging said container toprovide opposed bag-like receptacles, one receptacle adapted to containdried plasma and the other receptacle adapted to contain distilledwater, fluid communication between said receptacles for restoring saiddried plasma to liquid form being had by fracture of said clampingmeans, and a discharge tube communicating with the interior of saidcontainer to permit the dispensing of restored plasma from saidapparatus.

HILTON W. ROSE.

References Cited in the file of this patent UNITED STATES PATENTS NumberName Date 605,178 Ferguson June 7, 1.898 1,159,160 Beringer Nov. 2, 19151,786,090 Schmidt et a1 Dec. 27, 1920 2,253,571 Miller Aug. 26, 19412,328,569 McGaw Sept. 7, 1943 2,362,025 Price Nov. 7, 1944 2,362,537Butler Nov. 14, 1944 2,409,734 Bucher Oct. 22, 1946 2,483,636 HardestyOct. 4, 1949 FOREIGN PATENTS Number Country Date 116,351 Great BritainJune 10, 1918

